Heparin Binding Motifs and Biofilm Formation by Candida albicans
…Candida albicans is a leading pathogen in infections of central venous catheters, which are frequently infused with heparin. Binding of C. albicans to medically relevant concentrations of soluble and plate-bound heparin was demonstrable by confocal microscopy and ELISA assay. A sequence-based search identified 34 C. albicans surface proteins containing at least one match to linear heparin binding motifs (HBM)…
Julianne V. Green1, Kris I. Orsborn1, Minlu Zhang2, Queenie K.-G. Tan3, Kenneth D. Greis4, Aleksey Porollo5,6, David R. Andes7, Jason Lu Long6 and Margaret K. Hostetter
J Infect Dis. (2013) doi: 10.1093/infdis/jit391
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Functional Differentiation of Small Heat Shock Proteins in Diapause-Destined Artemia Embryos
…Encysted embryos of Artemia franciscana cease development and enter diapause, a state of metabolic suppression and enhanced stress tolerance. The development of diapause-destined Artemia embryos is characterized by the coordinated synthesis of the small heat shock proteins (sHsps) p26, ArHsp21 and ArHsp22, the latter stress inducible in adults. The amounts of sHsp mRNA and protein varied…
Allison M. King, Jantina Toxopeus, Thomas H. MacRae
DOI: 10.1111/febs.12442
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Overexpression of the Escherichia coli TolQ protein leads to a null-FtsN-like division phenotype
…Resolved proteins were transferred to a polyvinylidene fluoride membrane (Millipore Corp. Bedford, MA) and probed with a monospecific polyclonal rabbit antiserum raised against a synthetic peptide corresponding to TolQ residues 47-62 (generated by Pacific Immunology, San Diego, CA), and visualized using an anti-rabbit immunoglobulin horseradish peroxidase conjugate and enhanced chemiluminescence (ECL)…
Mary A. Teleha1,2, Adam C. Miller2, Ray A. Larsen
Microbiology Open 2 JUL 2013 DOI: 10.1002/mbo3.101
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Estrogen Receptor-α Variant, ER-α36, is Involved in Tamoxifen Resistance and Estrogen Hypersensitivity
…Antiestrogens such as tamoxifen provided a successful treatment for ER-positive breast cancer for the past two decades. However, most breast tumors are eventually resistant to tamoxifen therapy. The molecular mechanisms underlying tamoxifen resistance have not been well established. Recently, we reported that breast cancer patients with tumors expressing high concentrations of ER-α36…
XianTian Zhang and Zhao-Yi Wang
Endocrinology June 1, 2013 vol. 154 no. 6 1990-1998
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Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis
…Deregulation of the non-receptor tyrosine kinase ACK1 (Activated Cdc42-associated kinase) correlates with poor prognosis in cancers and has been implicated in promoting metastasis. To further understand its in vivo function, we have characterized the developmental defects of a null mutation in Drosophila Ack, which bears a high degree of sequence similarity to…
Abbas M. Abdallah, Xin Zhou, Christine Kim, Kushani K. Shah, Christopher Hogden, Jessica A. Schoenherr, James C. Clemens, Henry C. Chang
Developmental Biology Volume 378, Issue 2, 15 June 2013, Pages 141–153
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