Heparin Binding Motifs and Biofilm Formation by Candida albicans

…Candida albicans is a leading pathogen in infections of central venous catheters, which are frequently infused with heparin. Binding of C. albicans to medically relevant concentrations of soluble and plate-bound heparin was demonstrable by confocal microscopy and ELISA assay. A sequence-based search identified 34 C. albicans surface proteins containing at least one match to linear heparin binding motifs (HBM)…
Julianne V. Green1, Kris I. Orsborn1, Minlu Zhang2, Queenie K.-G. Tan3, Kenneth D. Greis4, Aleksey Porollo5,6, David R. Andes7, Jason Lu Long6 and Margaret K. Hostetter
J Infect Dis. (2013) doi: 10.1093/infdis/jit391

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